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An unrelenting series of winter storms and an outbreak of cold air have killed several people across a half-dozen states since Friday. Now, another round of extreme cold and snow will march across the central and eastern US, setting up more hazardous travel and a brutally-cold weekend.

• More than two dozen storm-related deaths: At least 33 people have died across nine states since January 12. Fatalities have been reported in Arkansas, Illinois, Kansas, Mississippi, New York, Oregon, Pennsylvania, Tennessee and Wisconsin. In Tennessee, where seven fatalities have been reported, a box truck driver was killed Monday evening when he lost control of the vehicle on a snowy Knoxville highway and careened into a tractor-trailer, police said. Five people died in Pennsylvania when their minivan lost control on a snow-covered I-81, the coroner’s office in Lackawanna County said.

• Another round of snow and cold coming: More accumulating snow is likely from the Midwest to the East on Friday. Light totals could once again blanket Washington, DC, and New York City soon after their nearly-two year wait for an inch of snow ended early this week. Read on for a more detailed forecast.

• Ice knocks out power, creates treacherous travel in Northwest: Freezing rain and wind pelting the Pacific Northwest knocked out power to more than 85,000 homes and businesses in Oregon Wednesday morning amid frigid temperatures. Icy roadways and downed trees and power lines created dangerous travel conditions that triggered road closures Tuesday night and Wednesday. A nearly 50 mile-stretch of I-84 from west of Portland to the eastern side of the Oregon Cascades was shut down Tuesday night and early Wednesday due to the ice threat, according to the state’s department of transportation.

• Buffalo, New York, drivers face snowy conditions: Lake-effect snow warnings are in effect in Buffalo until Thursday night. The surrounding area could see 1 to 3 feet of localized snowfall and wind gusts up to 40 mph. More than 30 inches of snow had fallen south of Buffalo in Lackawanna, New York, as of Wednesday morning. “Travel could be very difficult to impossible. The hazardous conditions could impact the morning or evening commutes,” the weather service warned.